DIVERCHIM's business has been built around its unique chemistry skills and experience in synthesizing small molecules, amino acids, peptides or pseudopeptides using cutting-edge chemical synthetic approaches alongside classical methodologies.
DIVERCHIM earned a reputation for completing even the most challenging syntheses.
DIVERCHIM carries out syntheses of the inquired structures in milligram to kilogram scales as well as under cGMP conditions, using technical package from customers, experience of DIVERCHIM youth and mastered know-how intertwined teams and available scientific publications.
OUR STRENGTHS
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Design and synthesis of custom and focused libraries
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Design, development and optimization of chemical routes
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Custom single compounds synthesis in mg to kg scale (non exhaustive list)
- Reference compounds
- Lead analogues
- Metabolites
- Fragment synthesis
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Stereochemical assessment, enantiomer separation, enantiomeric excess determination
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Preparative chromatography
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Impurity isolation and identification
OUR EXPERIENCE
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Lipid chemistry
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Steroid and Secosteroid chemistry
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Cyclopropanation chemistry
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Pyrrolidine chemistry
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Oxetane and spiro oxetane chemistry
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Carbohydrate chemistry
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Natural products synthesis
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Haptens
OUR MAIN SYNTHETIC CAPACITIES
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Photochemistry
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Pressure chemistry
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Microwave chemistry
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Ozonolysis
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Organometallic chemistry
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Low temperature chemistry
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Sulphure chemistry
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Sulfide chemistry
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Swern oxidation
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Ellmann reagent
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Carbon monoxide chemistry
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Cold chemistry: D, 13C, 15N, 18O
OUR EQUIPMENTS
In our new site of Roissy-en-France, DIVERCHIM state-of-the-art labs are fully equipped to ensure a large diversity of chemistry:
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Doubled-jacketed class reactors (up to 50L, -105 °C - +180°C)
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Pressure reactors (0.25-1 L, 2-7.5 L 200 psi max)
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Photochemical reactor (0.6 – 20 L, 500- 1000 W)
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Ozonolysis reactor (10 g/h O3)
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Short path discilation KDL5
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25 L cryogenic reactor
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Micro-waves reactor with automatic sampler unit (4 x 20 mL)
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Combinatorial and parallel chemistry equipments
DIVERCHIM’s analytical laboratory ensures the quality, reliability, swiftness and confidentiality of the synthesized molecules.
One example of challenging synthesis completion by DIVERCHIM
DIVERCHIM developed in-house the synthesis of NAD 556 (19 steps). The first key step is a photochemical reaction leading to the creation of a 6 fused rings scaffolds. A second key step is the creation of three asymmetric centers. This development was based on 3 FTE during 5 months.
CATALOG
Creation of novel building blocks, templates, scaffolds, privileged structures, small fragments or screening compounds is critical to maintain originality, diversity and intellectual properties in drug discovery, agrochemical or cosmetics programs. In this purpose, and with its in-house expertise and its new developed synthetic methodologies,
DIVERCHIM produced 1,500 unique catalog compounds over the years.
These products represent over unique 500 chemical scaffolds that include among others lipid derivatives, steroids, heterocycles, cyclopropanes or spiro compounds. DIVERCHIM is thus proposing a high chemically diverse catalog compounds that can be ordered directly from milligrams to kilogram scale.
This catalog is in constant evolution to include regularly new innovative products coming from our internal research for new synthetic methodologies or new original structures.
DIVERCHIM's catalog collection summarizes a part of the synthetic experience of its youth and mastered know-how intertwined teams. We would be happy to provide quotes for even the most specultaive projects. We are looking forward to discuss more in detail your project.
INNOVATIVE TECHNOLOGIES
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New process for cyclopropanation
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New process for pseudo-peptides
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New process for α and β aminophosphonic acids
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New process for amino-acids
All you need to run your factory !
